Intrauterine growth restriction - impact on cardiovascular diseases later in life
نویسندگان
چکیده
Intrauterine growth restriction (IUGR) is a fetal pathology which leads to increased risk for certain neonatal complications. Furthermore, clinical and experimental studies revealed that IUGR is associated with a significantly higher incidence of metabolic, renal and cardiovascular diseases (CVD) later in life. One hypothesis for the higher risk of CVD after IUGR postulates that IUGR induces metabolic alterations that then lead to CVD.This minireview focuses on recent studies which demonstrate that IUGR is followed by early primary cardiovascular alterations which may directly progress to CVD later in life.
منابع مشابه
Intrauterine programming
In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. Changes in the intrauter...
متن کاملMRI detection of asymmetric intrauterine growth restriction due to placental insufficiency
Purpose: Intrauterine growth restriction (IUGR) is defined as a fetus that is not maintaining its genetic growth potential in utero. This reduced growth is often caused by placental insufficiency resulting in decreased nutrient and oxygen supply to the fetus. To increase the likelihood of survival, fetal adaptations occur, which include brain sparing leading to asymmetric growth restriction, al...
متن کاملPregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
Plentiful evidence now links low birth weight due to intrauterine growth restriction and increased risk of vascular disease in later adult life. This is considered to be partly the result of programming through fetal nutrition. In contrast, much less attention has been focused on the relation between adverse pregnancy outcomes, such as pre-eclampsia, gestational diabetes, preterm delivery, and ...
متن کاملIntrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants
Intrauterine growth restriction is associated with increased risk for adult metabolic syndrome and cardiovascular disease, which seems to be related to altered food preferences in these individuals later in life. In this study, we sought to understand whether intrauterine growth leads to fetal programming of the hedonic responses to sweet. Sixteen 1-day-old preterm infants received 24% sucrose ...
متن کاملIntrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats.
Epidemiological studies revealed an association between IUGR (intrauterine growth restriction) and an increased risk of developing CVDs (cardiovascular diseases), such as atherosclerosis or hypertension, in later life. Whether or not IUGR contributes to the development of atherosclerotic lesions, however, is unclear. We tested the hypothesis that IUGR aggravates experimentally induced vascular ...
متن کامل